Table 2.
Effect of curcumin on dLAN induced behavioural and biochemical alterations in mice.
| Behavioural Parameters | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| S.No. | Test | Parameters | Group | One-Way ANOVA | |||||
| 1 | OFT | dLAN | dLAN + Cur50 | dLAN + Cur100 | dLAN + Cur150 | F | df | p | |
| NLC (n) | 97.25 ± 1.47 | 107.75 ± 1.70 a | 120.00 ± 4.39 b | 124.25 ± 2.75 c | 73.17 | 12 | p < 0.001 | ||
| CSE (n) | 3.45 ± 0.42 | 4.50 ± 0.57 a | 5.50 ± 0.57 b | 6.25 ± 0.5 c | 21.65 | 12 | p < 0.001 | ||
| CSD (s) | 7.91 ± 0.58 | 8.11 ± 0.43 | 9.56 ± 0.45 | 14.37 ± 1.81 a | 36.22 | 12 | p < 0.001 | ||
| RR (n) | 23.25 ± 1.50 | 30.00 ± 1.82 a | 39.00 ± 1.41 b | 40.25 ± 0.95 c | 120.80 | 12 | p < 0.001 | ||
| 2 | MWM | TSFP (s) | 64.25 ± 1.70 | 58.39 ± 0.74 a | 55.87 ± 1.39 b | 42.76 ± 0.50 c | 232.80 | 12 | p < 0.001 |
| TSPQ (s) | 23.25 ± 1.70 | 26.41 ± 0.72 a | 32.50 ± 1.53 b | 44.82 ± 1.27 c | 194.70 | 12 | p < 0.001 | ||
| 3 | NOR | T2/T1 | 0.48 ± 0.05 | 0.63 ± 0.018 a | 0.94 ± 0.04 b | 1.19 ± 0.04 c | 227.30 | 12 | p < 0.001 |
| Biochemical Parameters | |||||||||
| 4 | MDA (nM/mg) | 3.17 ± 0.0476 | 2.66 ± 0.09 a | 1.89 ± 0.14 b | 1.52 ± 0.09 c | 167.40 | 12 | p < 0.001 | |
| 5 | SOD (unit/mg) | 2.44 ± 0.219 | 3.56 ± 0.10 a | 4.74 ± 0.18 b | 5.55 ± 0.21 c | 302.70 | 12 | p < 0.001 | |
| 6 | CAT (unit/mg) | 2.33 ± 0.08 | 2.64 ± 0.06 | 3.04 ± 0.11 a | 3.82 ± 0.13 b | 101.00 | 12 | p < 0.001 | |
Non-parametric one-way ANOVA with a posthoc Dunken’s test was employed to compare the behavioural results between dLAN exposed vs. dLAN treated groups. Two-way ANOVA test was employed to compare the biochemical result between dLAN exposed vs. dLAN treatment group. Mean values bearing the dissimilar alphabets are statistically different at group level (p < 0.001).OFT = open field test; MWM = Morris Water Maze; NOR = novel object recognition; NLC = number of line cross; CSE = centre square entry; CSD = centre square duration; RR = rearing; TSFP = time spent to find platform; TSPQ = time spent in platform quadrant; T2/T1 = time spent with novel object/time spent with familiar object; MDA = malondialdehyde; SOD = superoxide dismutase; CAT = catalase; n = number; s = second.