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. 2020 Sep 21;12(9):2696. doi: 10.3390/cancers12092696

Figure 5.

Figure 5

Expression of Wnt and GSK-3 molecules in hBM-MSCs. (A) Representative Western blot analysis (Figure S3) of Wnt components in AML-hBM-MSC (hBM-MSCs *) and hBM-MSCs from normal donors. Images are representative of 12 hBM-MSC and 18 hBM-MSC * samples. (B) Wnt activity according to GFP signal in THP1 cells expressing the gene reporter CSL-TCF/LEF-GFP. Transfected cells were cultured either alone or in presence of hBM-MSCs or in medium supplemented with Wnt-3a (25 ng/mL). (C) hBM-MSC viability in growth medium supplemented with increasing concentrations of Wnt and GSK-3 inhibitors. Data are representative of at least 4 independent experiments. * p < 0.05.