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Proposed inhibition mechanism of the IFN-γ-inducible protein GBP5 on RSV infection. RSV infection induces IFN-γ production, which stimulates GBP5 expression. In the presence of GBP5, the RSV SH protein, which is an important viroporin, is oversecreted from the cells, resulting in defective RSV, whereas infectious RSV was produced in the absence of GBP5. Meanwhile, RSV infection upregulates DZIP3 expression, which as an E3 ligase induces GBP5 degradation through the proteasomal pathway.
