FIG 4.
Common ISGs in IEC organoids are highly stimulated and consist of canonical antiviral genes. (A) Log2-fold changes from RNA-seq of genes stimulated by IFN-β but not IFN-λ (337) (IFN-β specific) or genes stimulated by both IFN-β and IFN-λ (190) (common). (B) Comparison of log2-fold changes for common ISGs following stimulation by IFN-β or IFN-λ. Lines indicate gene identity across treatment groups. (C) Selected pathways differentiating the indicated ISG categories. “padj” is the P value adjusted for multiple comparisons. For a complete list of pathways, see Data Set S4 in the supplemental material. Statistical significance was determined by a Mann-Whitney test. ****, P < 0.0001.