TABLE 3.
ICV reassortants based on HE lineage
Lineage/sublineage representatives are in bold type, and viruses characterized in this study are in italics.
HE lineage/sublineage indicated as follows: T, Taylor; M, Mississippi; Y, Yamagata; K, Kanagawa; A, Aichi; S, Sao Paulo (S1, S2); mismatches compared to the HE lineage/sublineage are highlighted. For MP (CM1 and CM2) and NS (NS1 and NS2), within gene fragment recombination events are boxed. na, full-length open reading frame sequence not available. For each virus, we elected to relate everything back to the HE lineage, as assigned in Fig. S2D in the supplemental material, when looking for reassortants and the way in which the other six genes grouped according to the HE lineage (Fig. S2A to C and E to I). Using this method, a number of the HE lineage representative viruses, notably C/Kanagawa/1/76, are clearly reassortants themselves. Only two viruses from the recent outbreaks in Hong Kong, both from the 2018 outbreak, appear to be reassortant.