FIG 4.

No difference in viremia or survival of mice inoculated with E330V-c14 versus E330L-c14. Groups of five to six 18-wko male AG129 mice were inoculated s.c. in their footpads with 10³ PFU of either ZIKV E330V-ZIKV-14 (dark blue) or ZIKV E330L- ZIKV-14 (light blue). (A) Survival curve of mice inoculated i.c. with the ZIKV strains. No significant difference in survival of mice (a log-rank [Mantel-Cox] test was used to test for significance). (B) Mean viremia (PFU/ml) of mice inoculated with the ZIKV strains. No significant difference in mean peak viremia data (a two-way ANOVA with multiple comparisons was used to test for significance).