Table 5.
Association of the MIF promoter polymorphisms with multiple complications *.
| MIF Polymorphism | Multiple Complications * (N = 139) | p-Value | ||||||
|---|---|---|---|---|---|---|---|---|
| Patients Carrying this Allele/Genotype | Patients NOT Carrying this Allele/Genotype | |||||||
| N | Incidence, % | N | Incidence, % | OR | (95% CI) | |||
|
-CATT repeat
allele carriers (rs3063368) |
||||||||
| CATT 5 | 50 | 10.3 | 89 | 14.2 | 0.69 | (0.47–1.01) | 0.055 | |
| CATT 6 | 120 | 12.5 | 19 | 12.0 | 1.06 | (0.62–1.88) | 0.898 | |
| CATT 7 | 49 | 17.7 | 90 | 10.7 | 1.79 | (1.20–2.65) | 0.003 | |
| Genotypes | ||||||||
| G>C (rs755622) |
||||||||
| GG | 80 | 10.1 | 59 | 16.7 | 0.59 | (0.40–0.86) | 0.005 | |
| GC | 55 | 16.8 | 84 | 10.7 | 1.69 | (1.15–2.47) | 0.007 | |
| CC | 4 | 15.4 | 135 | 12.4 | 1.29 | (0.32–3.87) | 0.554 | |
| CATT repeat (rs3063368) | ||||||||
| CATT 5,5 | 4 | 5.6 | 135 | 12.9 | 0.40 | (0.10–1.11) | 0.092 | |
| CATT 5,6 | 33 | 9.6 | 106 | 13.8 | 0.66 | (0.42–1.02) | 0.050 | |
| CATT 5,7 | 13 | 18.1 | 126 | 12.1 | 1.61 | (0.78–3.06) | 0.140 | |
| CATT 6,6 | 53 | 12.5 | 86 | 12.4 | 1.01 | (0.69–1.48) | 1.000 | |
| CATT 6,7 | 34 | 18.0 | 105 | 11.3 | 1.72 | (1.09–2.66) | 0.015 | |
| CATT 7,7 | 2 | 12.5 | 137 | 12.5 | 1.00 | (0.11–4.45) | 1.000 | |
|
Individual
genotype combinations † |
||||||||
| CATT 5,5-GG (6.1%) | 4 | 5.9 | 135 | 12.9 | 0.42 | (0.11–1.16) | 0.126 | |
| CATT 5,6-GG (29.5%) | 32 | 9.7 | 107 | 13.6 | 0.68 | (0.44–1.05) | 0.091 | |
| CATT 6,6-GG (32.3%) | 44 | 12.2 | 95 | 12.6 | 0.97 | (0.65–1.44) | 0.923 | |
| CATT 6,6-CG (5.6%) | 9 | 14.3 | 130 | 12.4 | 1.18 | (0.50–2.49) | 0.693 | |
| CATT 5,7-CG (6.2%) | 13 | 18.4 | 126 | 12.0 | 1.70 | (0.83–3.25) | 0.127 | |
| CATT 6,7-CG (15.8%) | 32 | 18.2 | 107 | 11.4 | 1.73 | (1.08–2.70) | 0.018 | |
The incidence of multiple complications was higher among patients carrying the CATT7 allele, in patients with the GC or CATT 6,7 genotype, and in patients with the genotype combinations CATT 5,7-CG and CATT 6,7-CG. CI, confidence interval; OR, odds ratio; SNP, Single nucleotide polymorphism; CATT7x, patients carrying at least one CATT7 allele. † genotype combinations with a frequency of > 5%. * Patients affected by at least two of the predefined organ dysfunctions. † defined as at least two of the predefined organ dysfunctions. Data presented as absolute numbers and percentage. p-value calculated by Fisher’s exact test; bold fonts indicate p-values < 0.05.