Table 6.
Association of the MIF promoter polymorphisms with death.
| MIF Polymorphism | Death (N = 8) | p-Value | ||||||
|---|---|---|---|---|---|---|---|---|
| Patients Carrying This Allele/Genotype | Patients NOT Carrying This Allele/Genotype | |||||||
| N | Incidence, % | N | Incidence, % | OR | (95% CI) | |||
|
CATT repeat
allele carriers (rs3063368) |
||||||||
| CATT 5 | 2 | 0.4 | 6 | 1.0 | 0.43 | (0.04–2.40) | 0.478 | |
| CATT 6 | 7 | 0.7 | 1 | 0.6 | 1.16 | (0.15–52.80) | 1.000 | |
| CATT 7 | 5 | 1.8 | 3 | 0.4 | 5.12 | (0.99–33.14) | 0.026 | |
| Genotypes | ||||||||
| G>C (rs755622) |
||||||||
| GG | 3 | 0.4 | 5 | 1.4 | 0.28 | (0.04–1.43) | 0.118 | |
| GC | 5 | 1.5 | 3 | 0.4 | 4.05 | (0.78–26.20) | 0.053 | |
| CC | 0 | 0 | 8 | 0.7 | 0.00 | (0.00–19.77) | 1.000 | |
| CATT repeat (rs3063368) | ||||||||
| CATT 5,5 | 0 | 0 | 8 | 0.8 | 0.00 | (0.00–6.75) | 1.000 | |
| CATT 5,6 | 1 | 0.3 | 7 | 0.9 | 0.32 | (0.01–2.49) | 0.447 | |
| CATT 5,7 | 1 | 1.4 | 7 | 0.7 | 2.09 | (0.05–16.59) | 0.415 | |
| CATT 6,6 | 2 | 0.5 | 6 | 0.9 | 0.54 | (0.05–3.06) | 0.717 | |
| CATT 6,7 | 4 | 2.1 | 4 | 0.4 | 4.99 | (0.92–26.98) | 0.032 | |
| CATT 7,7 | 0 | 0 | 8 | 0.7 | 0.00 | (0.00–33.33) | 1.000 | |
|
Individual
genotype combinations * |
||||||||
| CATT 5,5-GG (6.1%) | 0 | 0 | 8 | 0.8 | 0.00 | (0.00–7.07) | 1.000 | |
| CATT 5,6-GG (29.5%) | 1 | 0.3 | 7 | 0.9 | 0.34 | (0.01–2.66) | 0.449 | |
| CATT 6,6-GG (32.3%) | 2 | 0.6 | 6 | 0.8 | 0.70 | (0.07–3.93) | 1.000 | |
| CATT 6,6-CG (5.6%) | 0 | 0 | 8 | 0.8 | 0.00 | (0.00–7.68) | 1.000 | |
| CATT 5,7-CG (6.2%) | 1 | 1.5 | 7 | 0.7 | 2.18 | (0.05–17.39) | 0.401 | |
| CATT 6,7-CG (15.8%) | 4 | 2.3 | 4 | 0.4 | 5.44 | (1.00–29.44) | 0.025 | |
The incidence of death was higher among patients carrying the CATT7 allele, in patients with the CATT 6,7 genotype, and in patients with the genotype combination CATT 6,7-CG.; OR, odds ratio; SNP, Single nucleotide polymorphism; CATT7, patients carrying at least one CATT7 allele. * genotypes with a frequency of > 5%. Data presented as absolute numbers and percentage. p-value calculated by Fisher’s exact test; bold fonts indicate p-values < 0.05.