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. 2020 Sep 5;9(9):2873. doi: 10.3390/jcm9092873

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Retrospective stratification of patients via D50 for the cumulative probability of the initiation of therapies after symptom onset. Patients were divided in subgroups of high disease aggressiveness (D50 < 30 months, slim graphs) and low disease aggressiveness (D50 ≥ 30 months, bold graphs). The time is calculated from symptom onset until (A) initiation of assisted ventilation (invasive or non-invasive), (B) implantation of a feeding-tube. Notably, both events occurred significantly earlier in the group with a lower D50 (Log Rank p < 0.001).