Table 7.

Summary of characteristics of main “dry” biomarkers for Alzheimer’s disease.

Imaging Biomarker	Type of Information	Early Changes Predictive for AD	Limits
MRI Imaging	N		need patients’ collaboration time-consuming analyses
Morphometric technique Hippocampal segmentation DTI		most studied, good predictive value promising tool, more studies are needed
Functional technique fMRI ALS		promising tool, more studies are needed more studies are needed
Nuclear Medicine Imaging
Perfusion SPECT PET Imaging FDG PET	N		invasiveness, ionizing radiation invasiveness, ionizing radiation expansive,
Amyloid PET Tau PET	N P P		invasiveness, ionizing radiation expansive low specificity small studies

D, Aβ dysfunction; N, neurodegeneration; P, pathognomonic; AD, pathological deposition of amyloid or fibrillary tau.