Table 1.
Effect of Piperine on Glutathione and Antioxidant Armory.
| Group I | Group II | Group III | Group IV | |
|---|---|---|---|---|
| Reduced Glutathione (GSH; nmol mg protein) |
214.72 ± 11.2 | 92.32 ± 8.31 *** | 141.39 ± 11.3 # | 197.52 ± 15.8 ### |
| Oxidized Glutathione (GSSG; nmol mg protein) |
31.02 ± 3.23 | 79.86 ± 3.03 *** | 62.03 ± 4.91# | 41.52 ± 5.02 ### |
| GSH/GSSG Ratio |
6.921 ± 0.82 | 1.156 ± 0.21 *** | 2.279 ± 0.33 # | 4.759 ± 0.61 ### |
| GPx (nmol/ min/mg protein) |
201.23 ± 17.1 | 82.43 ± 7.25 *** | 160.28 ± 14.7 ## | 182.46 ± 17.3 ### |
| GR (nmol min/min/mg protein |
201.44 ± 19.5 | 84.25 ± 9.22 *** | 139.12 ± 17.8 ## | 189.23 ± 20.9 ### |
| SOD (units/ min/mg protein |
10.63 ± 1.93 | 4.01 ± 0.41 *** | 7.11 ± 0.73 ## | 9.03 ± 0.97 ### |
| Catalase (nmol H2O2 consumed/min/mg protein |
10.23 ± 1.62 | 4.82 ± 0.48 *** | 5.94 ± 0.33 # | 8.32 ± 0.72 ### |
| H2O2 (nmol of H2O2 /g tissue) |
185.2 ± 17.4 | 403.5 ± 32.1 *** | 256.9 ± 21.3 ## | 205.7 ± 19.3 ### |
Group-I: Control; Group-II: DMH-administered group (20 mg/kg BW); Group-III: DMH rats treated with Piperine (30 mg/kg b.wt.); Group-IV: DMH rats treated with Piperine (60 mg/kg b.wt.). Data are represented as mean ± S.E.M (n = 10).