Table 2.
Effect of Piperine on Serum Levels of Inflammatory Cytokines (IL-6, TNF-α, Cox-2, iNOS and PGE-2).
| Group-I | Group-II | Group-III | Group-IV | |
|---|---|---|---|---|
| IL-6 (pg/mL) | 834.12 ± 42.34 | 2023.32 ± 187.4 *** | 1342.07 ± 146.6 # | 1054.83 ± 94.50 ### |
| TNF-α (pg/mL) | 522.83 ± 40.27 | 1443.62 ± 138.2 *** | 987.83 ± 105. # | 774.31 ± 55.49 ## |
| Cox-2 (pg/mL) | 921.62 ± 63.11 | 1998.23 ± 92.3 *** | 1532.13 ± 144.1 ## | 1098.23 ± 68.70 ### |
| iNOS (pg/mL) | 774.52 ± 87.63 | 1638.65 ± 106.1 *** | 1310.22 ± 119.4 ## | 897.35 ± 77.42 ### |
| PGE-2 (pg/mL) | 814.89 ± 99.10 | 1547.86 ± 165.2 *** | 1211.17 ± 113.4 ## | 998.64 ± 94.71 ### |
Group-I: normal control; Group-II: DMH-administered group (20 mg/kg BW); Group-III: DMH rats treated with Piperine (30 mg/kg b.wt.); Group-IV: DMH rats treated with Piperine (60 mg/kg b.wt.). Data are represented as mean of 10 rats ± S.E.M.