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D10 for X-rays (a), D10 for carbon ions (b), and relative biological effectiveness (RBE) of carbon ions (c) for human papillomavirus-positive (pos) or -negative (neg) head-and-neck squamous cell carcinoma cell lines. RBE data for the HSGc-C5 cell line (HSG) were used as the reference. Black lines show median values. p-values as assessed by the Mann–Whitney U-test are shown.
