Table 3.
Spearman correlation between SFRP1 expression, waist circumference, and inflammatory cytokines’ expression by epithelial cells and adipocytes in all women.
| Continuous Variables | Cytokines | Epithelial Cells | Adipocytes | ||||
|---|---|---|---|---|---|---|---|
| N | Rho | p-Value | N | Rho | p-Value | ||
| SFRP1 | Pro-inflammatory markers: | ||||||
| Leptin | 155 | 0.32 | <0.0001 | 72 | 0.043 | 0.72 | |
| COX-2 | 156 | −0.060 | 0.45 | - | - | ||
| CRP | 158 | 0.14 | 0.090 | - | - | ||
| SAA1 | 152 | 0.15 | 0.070 | - | - | ||
| STAT3 | 156 | 0.038 | 0.64 | - | - | ||
| TNF-α | 157 | 0.21 | 0.007 | 62 | −0.078 | 0.54 | |
| IL-6 | 156 | 0.21 | 0.009 | 72 | 0.041 | 0.73 | |
| IL-8 | 157 | 0.040 | 0.64 | - | - | ||
| Anti-inflammatory markers: | |||||||
| Lactoferrin | 152 | 0.070 | 0.36 | - | - | ||
| IL-10 | 148 | 0.040 | 0.67 | - | - | ||
| TGF-β | 158 | −0.024 | 0.76 | - | - | ||
| Waist circumference | Pro-inflammatory markers: | ||||||
| Leptin | 155 | −0.16 | 0.046 | 72 | 0.45 | <0.0001 | |
| COX-2 | 156 | −0.080 | 0.31 | - | - | ||
| CRP | 158 | −0.22 | 0.0060 | - | - | ||
| SAA1 | 152 | 0.036 | 0.66 | - | - | ||
| STAT3 | 156 | 0.087 | 0.28 | - | - | ||
| TNF-α | 157 | −0.26 | 0.00091 | 62 | 0.16 | 0.21 | |
| IL-6 | 156 | −0.25 | 0.0016 | 72 | 0.37 | 0.001 | |
| IL-8 | 157 | −0.045 | 0.57 | - | - | ||
| Anti-inflammatory markers: | |||||||
| Lactoferrin | 152 | −0.070 | 0.37 | - | - | ||
| IL-10 | 148 | −0.11 | 0.20 | - | - | ||
| TGF-β | 158 | −0.0061 | 0.94 | - | - | ||
Abbreviations: SFRP1, secreted frizzled-related protein 1; IL-8, interleukin 8; IL-6, interleukin 6; TNF-α, tumor necrosis factor α; COX-2, cyclooxygenase 2; SAA1, serum amyloid A1; STAT3, signal transducer and activator of transcription 3; CRP, C-reactive protein; TGF-β, transforming growth factor β; IL-10, interleukin 10. The p-value < 0.05 is considered significant.