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. 2020 Aug 20;12(9):2358. doi: 10.3390/cancers12092358

Figure 5.

Figure 5

Effect of Romo1 suppression and TRAIL treatment on the tumor xenograft in vivo mouse model. (A,B) Effect of TRAIL treatment on the tumor xenograft in vivo mouse model established using BALB/c-nude mice injected subcutaneously with Romo1-deficient cells. Tumor growth (A) and body weight (B) after injecting shMock and shRomo1 HCT116 cell was monitored. (C,D) Representative images of tumor growth. (E) TUNEL assay in tumor tissues obtained from the xenograft mice. (Scale bar, 10 μm) (F) Sectioned tumor tissue was immunostained with the anti-Bax (red) and anti-Romo1 (green) antibodies. (Scale bar, 10 μm). *** stands for *** p < 0.001.