Table 2.
List of the altered regions in tumor tissue and in at least two CTCs of the same patient isolated at all access times.
| Chromosome:Start–End (bp) | Region/s | CTC ID Timepoint A | CTC ID Timepoint B | CTC ID Timepoint C | Reference |
|---|---|---|---|---|---|
| Patient P02 | |||||
| 16:81368788–82403137 | 16q23.3 | P02A__2 | P02B_1 | P02C_1, P02C_2 | |
| 21:40355250–43442658 | 21q22.2, 21q22.3 | - | P02B_1 | P02C_1 | [21] |
| Patient 04 | |||||
| 1:33248192–58929280 | 1p35.1, 1p34.3, 1p34.2, 1p34.1, 1p33, 1p32.3, 1p32.2 | P04A_5 | - | P04C_3 | |
| 1:156891657–162239674 | 1q23.1, 1q23.2, 1q23.3 | P04A_2, P04A_5 | P04B_2 | P04C_1, P04C_3 | [19,22,23,24] |
| 1:162239674–167163992 | 1q23.3, 1q24.1 | - | P04B_1 | P04C_1 | [19,22,23,24] |
| 1:231729524–234612196 | 1q42.2 | - | - | P04C_1, P04C_3 | [22,23,24] |
| 2:36278338–54693738 | 2p22.2, 2p22.1, 2p21, 2p16.3, 2p16.2 | P04A_6 | - | P04C_1, P04C_3 | |
| 3:72930104–74214062 | 3p13 | - | - | P04C_1, P04C_3 | |
| 5:0–2025694 | 5p15.33 | P04A_7, P04A_9 | - | P04C_3 | [21,25] |
| 6:19336170–21177710 | 6p22.3 | - | - | P04C_1, P04C_3 | |
| 7:36023910–36646646 | 7p14.2 | 04C458_7 | - | P04C_3 | |
| 7:151606990–156715054 | 7q36.1, 7q36.2, 7q36.3 | - | P04B_2 | P04C_1 | |
| 8:92927068–94286848 | 8q21.2 | P04A_8 | - | P04C_1, P04C_3 | |
| 8:121094607–123567334 | 8q24.12, 8q24.13 | P04A_9 | - | P04C_3 | |
| 9:109019168–109755681 | 9q31.2 | 04A459_9 | - | P04C_1 | |
| 10:124680720–129276108 | 10q26.13 | P04A_6 | - | P04C_3 | |
| 11:17862938–20072786 | 11p15.1 | P04A_2 | - | P04C_1 | |
| 11:112838832–119700100 | 11q23.2, 11q23.3 | P04A_2, P04A_5 | P04C_1 | ||
| 13:24308328–24860790 | 13q12.12 | - | - | P04C_1, P04C_3 | |
| 14:75318986–75871448 | 14q24.3 | P04A_9 | - | P04C_1 | |
| 14:94448360–96128388 | 14q32.13 | - | P04B_2 | P04C_1, P04C_3 | |
| 15:80279738–85999918 | 15q25.1, 15q25.2, 15q25.3 | P04A_2, P04A_5 | - | P04C_3 | |
| 16:84526686–87288996 | 16q24.1 | P04A_5 | P04B_1, P04B_2, P04B_3 | P04C_1 | |
| 17:17494630–19520324 | 17p11.2 | - | P04B_3 | P04C_3 | |
| 17:70159110–70715136 | 17q24.3 | - | P04B_1 | P04C_3 | |
| 18:77160526–78077248 | 18q23 | - | P04B_1 | P04C_1, P04C_3 | [21] |
| 20:42723728–47051680 | 20q13.12, 20q13.13 | P04A_9 | P04B_3 | P04C_1 | |
| 22:34700614–35725876 | 22q12.3 | P04A_5, P04A_7, P04A_9 | P04B_1 | P04C_1 | |
| X:13627396–13995704 | Xp22.2 | P04A_5 | - | P04C_1, P04C_3 | |
| Patient 07 | |||||
| 22:25992468–25992468 | 22q12.1, 22q12.2, 22q12.3 | P07A__1 | P07B_3 | P07C_2 | |
| Patient 09 | |||||
| 15:60636100–64190630 | 15q22.2 | - | P09B__1 | P09C_2 | |
| Patient 10 | |||||
| 16:82480932–85699185 | 16q23.3, 16q24.1 | P10A_1 | P10B__1 | P10C_1 |
Bp: base pair; CTC: circulating tumor cell; ID: identification code; q: long arm; p: short arm.