Table 3.
List of the enriched terms in CTCs.
| Enriched Terms | Term ID | CTCs | Samples | Genes |
|---|---|---|---|---|
| Natural killer cell activation involved in immune response | GO:0002323 | 10 | P02A__2; P03C_1; P07A__1; P09B__2; P08A__1; P09B__3; P09B__1; P10B_1; P11A_1; P12A_2 | CD244; CORO1A; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; KLRF2; VAMP7 |
| Response to dsRNA | GO:0043331 | 9 | P01A_6; P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P10B_1; P11A_1; P12A_2 | IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IRAK3; PDE12; PMAIP1; RFTN1; RIOK3; SLC3A2; TICAM1; TLR3 |
| Regulation of peptidyl-serine phosphorylation of STAT protein | GO:0033139 | 9 | P01A_6; P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P10B_1; P11A_1; P12A_2 | IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNG; IFNK; IFNW1; LIF |
| Positive regulation of peptidyl-serine phosphorylation of STAT protein | GO:0033141 | 9 | P01A_6; P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P10B_1; P11A_1; P12A_2 | IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNG; IFNK; IFNW1; LIF |
| Lymphocyte activation involved in immune response | GO:0002285 | 9 | P01A_6; P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P10B_1; P11A_1; P12A_2 | CD1C; CD244; EIF2AK4; F2RL1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; LCP1 |
| Natural killer cell activation | GO:0030101 | 8 | P02A_2; P07A_1; P08A_1; P09B_2; P09B_3; P09B_1; P11A_1; P12A_2 | BAG6; CASP8; CD2; CD244; ELF4; HNF1A; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IL12B; IL2; IL21R; KLRK1; NCR1; NCR3; PRDX1; SLAMF7; SNX27; ULBP1; ULBP2; ULBP3 |
| B cell proliferation | GO:0042100 | 8 | P01A_6; P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P11A_1; P12A_2 | BCL2; CD40; CD40LG; CD79A; CR2; CTPS1; GAPT; HSPD1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IL10; LEF1; MEF2C; MS4A1 |
| Cytidine to uridine editing | GO:0016554 | 7 | P01A_5; P04A9; P07A_1; P07C2; P08A_1; P09B_3; P11A_1 | A1CF; AICDA; APOBEC1; APOBEC2; APOBEC3A; APOBEC3B; APOBEC3C; APOBEC3D; APOBEC3F; APOBEC3G; APOBEC3H |
| T cell activation involved in immune response | GO:0002286 | 7 | P01A_6; P07A_1; P08A_1; P09B_2; P09B_1; P11A_1; P12A_2 | CD1C; EIF2AK4; F2RL1; FCER1G; ICAM1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; ITGAL; LCP1; LILRB1; SLC11A1; TNFSF18 |
| Lymphocyte proliferation | GO:0046651 | 7 | P02A_2; P07A_1; P08A_1; P09B_2; P09B_1; P11A_1; P12A_2 | BCL2; CD40; CD40LG; CD79A; CR2; CTPS1; ELF4; HELLS; HSPD1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IL10; MEF2C; MS4A1; MSN; PIK3CG; PPP3CB; TNFRSF4; TNFSF14 |
| Response to exogenous dsRNA | GO:0043330 | 7 | P01A_6; P07A_1; P08A_1; P09B_2; P09B_1; P11A_1; P12A_2 | CAV1; COLEC12; DDX58; DHX9; FLOT1; IFIH1; IFIT1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IRAK3; MUL1; PQBP1; RALB; RFTN1; SLC3A2; TICAM1; TLR3; TMEM173 |
| DNA cytosine deamination | GO:0070383 | 6 | P01A_5; P04A9; P07A_1; P07C2 P08A_1; P11A_1 | APOBEC3A; APOBEC3C; APOBEC3D; APOBEC3F; APOBEC3G; APOBEC3H |
| B cell differentiation | GO:0030183 | 6 | P01A_6; P07A_1; P08A_1; P09B_1; P11A_1; P12A_2 | ADAM17; AICDA; BLNK; CD79A; CEBPG; CLCF1; DNAJB9; HDAC5; HDAC9; HHEX; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNB1; IFNE; IFNK; IFNW1; IL11; ITGA4; JAK3; KIT; KLF6; LYL1; MSH2; NFAM1; NHEJ1; PLCG2; RAG1; RAG2; TCF3; TPD52; VCAM1 |
| Regulation of type I interferon-mediated signaling pathway | GO:0060338 | 6 | P07A_1; P08A_1; P09B_2; P09B_1; P11A_1; P12A_2 | CACTIN; CDC37; FADD; HSP90AB1; IFNA1; IFNA10; IFNA14; IFNA16; IFNA17; IFNA2; IFNA21; IFNA4; IFNA5; IFNA6; IFNA7; IFNA8; IFNAR1; IFNAR2; IFNB1; JAK1; NLRC5; PTPN1; PTPN11; PTPN6; TYK2; WNT5A; ZBP1 |
ID: identification code of the term; CTC: circulating tumor cell; GO: gene onthology; dsRNA: double strand RNA; STAT: Signal Transducer and Activator of Transcription.