Figure 1.

Schematic summary of the most relevant mutations, key features, and treatment options of rare melanomas. For each subtype, mutations are ordered by their prevalence. Main treatment strategies were ordered according to the decreasing efficacy outcomes, including the overall response rate, progression-free survival, and overall survival. Abbreviations: TMB, tumor mutational burden; UV, ultraviolet radiation; Mut, mutation; Amp, amplification; KIT, receptor tyrosine kinase (c-Kit); VEGFR, vascular endothelial growth factor receptor. *Fusion kinases involving ALK, ROS1, NTRK1, NTRK3, MET, RET, BRAF, and MAP3K8.