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. 2020 Oct 16;13:141. doi: 10.1186/s13041-020-00683-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CCVs were uncommon in presynaptic terminals of fast perfusion-fixed brains (a), but became more abundant (arrows in b) upon a 5 min delay in perfusion fixation (b). Samples were from cerebral cortex of the mouse brain, and SVs were not noticeably depleted or dispersed in the delayed perfusion-fixed brains (b). Bar graphs in upper panel of e represent means of seven pairs of samples (data from Additional file 5A). In dissociated hippocampal cultures, upon depolarization with high K⁺, synaptic vesicles were typically dispersed and depleted (d). CCVs (arrows in d) were sometimes seen more frequently in high K⁺ (d) than in control samples (c). A CCP (double arrowheads in d) was seen adjacent to the active zone (between two open arrows) of the synapse. Bar graphs in lower panel of e represent means of four experiments (data from Additional file 5B). Scale bar = 100 nm