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. 2020 Oct 15;17:304. doi: 10.1186/s12974-020-01969-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Reactivation of microglia-derived Il6 expression in IL6-DIO-ON^Cx3cr1 mice. a Serum IL-6 protein levels of LPS-injected IL6-DIO-Het, IL6-DIO-ON^Cx3cr1 and IL6-DIO-KO mice 1 day following 11 days of TAM treatment. b Left: IL6-DIO-ON^Cx3cr1 and IL6-DIO-KO mice were euthanized 1 month after TAM treatment and the brains were homogenized and incubated with CD11b+ antibody. Besides, the positive cell population was selected using columns with ferromagnetic spheres. Right: The reversion band (463 bp) was only seen in the brain CD11b+ fraction of IL6-DIO-ON^Cx3cr1 mice. All results are represented as mean ± SEM