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. 2020 Oct 15;17:304. doi: 10.1186/s12974-020-01969-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — IL6-DIO-ON^Cx3cr1 showed mild EAE-related symptoms. a Clinical course of MOG-IL6-DIO-Het, MOG-IL6-DIO-ON^Cx3cr1 and MOG-IL6-DIO-KO mice. Body weight (left) and clinical signs (middle) changes were observed in IL6-DIO-Het and IL6-DIO-ON^Cx3cr1 mice whereas IL6-DIO-KO mice were almost completely resistant to EAE. Area under the curve (AUC; right) was calculated from EAE clinical course for each mouse between days 21 and 27. b Clinical evaluation of EAE. IL6-DIO-ON^Cx3cr1 and IL6-DIO-KO mice were significantly less affected than IL6-DIO-Het mice. The incidence, disease onset, and time to peak were calculated using a clinical score ≥1. Results in (a) are represented as mean ± SEM, while (b) shows median and IQR (except for incidence and mortality). NA (not applicable) shows the impossibility to calculate the median (given the criterion for disease). ★p ≤ 0.05 vs. MOG-IL6-DIO-Het mice