Table 1.

Biological effects of LL-37 in psoriasis and lupus erythematosus.

LL-37-Mediated Pathogenic Events	Psoriasis	Lupus Erythematosus
LL-37 induces the release of inflammatory mediators by keratinocytes LL-37 induces keratinocyte migration and proliferation	+ +	+
LL-37 reduces keratinocytes apoptosis	+
LL-37/DNA complexes as autoantigens	+	+
LL-37/DNA complexes stimulate pDCs to high IFN-α production	+	+
LL-37/RNA complexes stimulate mDCs to high TNF-α and IL-6	+
Presence of LL-37-specific, IFN-γ positive CD4+ and CD8+ T cells	+
LL-37-specific T cells promote anti-LL-37 antibody production by B cells		+