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. 2020 Sep 11;9(9):2082. doi: 10.3390/cells9092082

Figure 7.

Figure 7

Quantitative analyses of axon regeneration. The length of the longest regrown axon was determined in the distal optic nerve stumps of mice with grafted control- (circles), GDNF- (diamonds), CNTF- (squares) and GDNF/CNTF- (pentagons) NS cells (a). While axons in control and GDNF-treated animals extended for only around 500 µm into the distal nerve stumps, axons in CNTF- and GDNF/CNTF-treated animals extended for up to 3400 and 2600 µm, respectively, distal to the lesion site. Arrowheads indicate mean values (n = 6 for each experimental group). The number of regrown axons in optic nerve sections from CNTF- (open bars) and GDNF/CNTF- (filled bars) treated animals at different positions distal to the lesion site (b). Note the similar number of regenerating axons in both experimental groups at all positions analyzed. Each bar represents the mean number (±SEM) of axons per 100 µm nerve width in 25 µm thick nerve sections from 6 animals. n.s.: not significant; ***: p < 0.001 according to one-way ANOVA followed by Bonferroni post-hoc test.