TABLE 3.
Sequential isolation of M. tuberculosis resistant isolates using AU1235a
| Strain nameb | MmpL3 SNPs | MIC in liquid medium (μM) |
||
|---|---|---|---|---|
| IDR-0541243 | SQ109 | AU1235 | ||
| H37Rv-LP | WT | 0.7 | 0.9 | 0.3 |
| LP-0334448-RM102 | F255L, L567P | 6 | 5 | 0.7 |
| LP-0497754-RM201 | F255L, L567P, F644L | 5 | 25 | 11 |
| LP-0334448-RM107 | F255L, V646M | 6 | 3 | 0.3 |
| LP-0497754-RM302 | F255L, V646M, F644I | 40 | 20 | 30 |
a
Resistant mutants were isolated on plates containing 5× MIC AU1235 and confirmed by streaking onto plates with 5× MIC.
b
Strain LP-0497754-RM201 was derived from strain LP-0334448-RM102; strain LP-0497754-RM302 was derived from strain LP-0334448-RM107.