Fig 1.

Study design and flowchart. ∗Drop-out before randomisation: one patient signed informed consent, but during the procedure primary clipping of the giant cerebral aneurysm was possible and an intracranial–intracranial cerebral bypass was no longer necessary. ^†ETCO₂ value that corresponds to Paco₂ (arterial carbon dioxide pressure) from arterial blood gas sampling. ^‡One patient developed arrhythmia after dobutamine administration. We did not exclude this patient entirely, but only excluded data obtained during the dobutamine intervention from our analyses. ABG, arterial blood gas; CI, cardiac index; ETCO₂, end-tidal carbon dioxide; Hb, haemoglobin; HR, heart rate; Ht, haematocrit; MAP, mean arterial pressure; SBP, systolic blood pressure; SV, stroke volume.