Table 2.
Change in haemodynamic parameters. Data from the dobutamine intervention in patient 6b were removed from the analyses, because arrhythmia occurred during dobutamine administration, making values obtained with the EV1000/FloTrac® system less reliable. ∗Statistically significant at a level of significance of P<0.05. †Differences were estimated using a Wilcoxon signed rank test comparing the effects of dobutamine with phenylephrine and reporting a pseudomedian because differences between paired samples were not fully symmetrically distributed around the median. CI, confidence interval; IQR, inter-quartile range; MAP, mean arterial pressure; SBP, systolic blood pressure.
| Haemodynamic parameters | Phenylephrine (median [IQR]) |
Dobutamine (median [IQR]) |
Between intervention difference (95% CI)† | P-value | ||||
|---|---|---|---|---|---|---|---|---|
| Reference | Intervention | Difference | Reference | Intervention | Difference | |||
| Cases (N = 10) | ||||||||
| Graft flow (ml min−1) | 15.5 [6.4–20.9] | 20.8 [7.5–32.5] | 3.6 [1.3–7.8] | 21.0 [6.4–27.5] | 21.6 [10.0–38.2] | 4.1 [1.7–12.0] | – 0.6 (–14.5 to 5.3) | 0.441 |
| MAP (mm Hg) | 91 [88–101] | 108 [104–118] | 16 [14–19] | 99 [93–103] | 96 [90–104] | –7 [–7 to 0] | 21 (12–31) | 0.004∗ |
| SBP (mm Hg) | 139 [123–155] | 169 [154–185] | 32 [26–33] | 146 [135–153] | 151 [135–167] | 5 [–1 to 20] | 24 (7–35) | 0.013∗ |
| Cardiac index (L min−1 m−2) | 3.0 [2.6–3.5] | 3.0 [2.6–4.0] | 0.1 [–0.2 to 0.3] | 2.7 [2.4–3.1] | 4.0 [3.4–5.2] | 1.1 [0.8–1.5] | –1.0 (–1.4 to –0.7) | 0.009∗ |
| Heart rate (beats min−1) | 53 [50–59] | 51 [47–59] | –1 [–2 to –1] | 53 [50–57] | 62 [57–64] | 5 [2–6] | –7 (–12 to –4) | 0.004∗ |
| Stroke volume (ml) | 57 [49–63] | 60 [55–68] | 4 [–0.5 to 7] | 54 [44–63] | 69 [62–80] | 13 [11–22] | –10 (–19 to –4) | 0.004∗ |