Figure 3.

Voronoi tessellation diagrams representing differentially expressed pathways at (a) level 1, (b) level 2 and (c) level 3 of the KEGG database in the skin of the fish at the late stage of the disease. Each polygon represents an ontology term, with their size corresponding to the numbers of genes involved in the associated pathway. To further explore the pathways differentially expressed between health states, we imported all DEGs (and associated logs values) to generate the Voronoi tessellations. Pathways colored in red are upregulated, and those in blue are downregulated in the fish at the late stage of the disease when compared to healthy fish. A quantile color scale was used to show differential expression.