Figure 1.

Experimental design. At time 0, status epilepticus (SE) was induced in male Wistar rats via lithium–pilocarpine administration. Three weeks after SE induction, rats were video monitored until the first spontaneous behavioral seizure was detected and then treated with levetiracetam (300 mg/kg/day) for one week. Four days after the end of the treatment, electrophysiological experiments were conducted; finally, animals were intracardially perfused, and brain dissection was performed.