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. 2020 Sep 11;10(9):634. doi: 10.3390/brainsci10090634

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Long-term potentiation (LTP) of the excitatory postsynaptic potential (EPSP) and population spike (PS) recorded in the dentate gyrus. LTP of the EPSP slope (top) and PS amplitude (bottom) in control (CONT) and epileptic (EPI) rats and control (CONT + LEV) and epileptic (EPI + LEV) rats after one week of levetiracetam (LEV) treatment (300 mg/kg/day) are presented as percentages of baseline (pretrain) values. LTP was induced with trains of 1500 µA, and pre- and post-train field extracellular potentials were evoked at intensities that produced 50% of the maximal PS from the input–output curve. Data are represented as the means + S.E.M., # p < 0.05 vs. EPI group; @ p < 0.05 vs. time = 5 min; * p < 0.05 vs. CONT and CONT+LEV groups. Three-way RM ANOVA followed by the Student–Newman–Keuls post-hoc test; n = 6 to 7 animals per group. Representative examples of traces showing pre- and post-train field extracellular potentials are presented in the bottom right.