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. 2020 Sep 1;9(9):2014. doi: 10.3390/cells9092014

Figure 5.

Figure 5

Representative images of atherosclerotic plaques in aortic root section (A) stained with hematoxylin–phloxine–saffron (HPS) from Ldlr−/−.Leiden mice fed a healthy chow diet for 28 weeks or fed a high-fat diet (HFD) for 28 weeks or fed a fast food diet (FFD) for 22 or 28 weeks. In addition, mice were fed the FFD and supplemented with a relatively low dose of OCA (10 mg/kg/d) from weeks 18 to 28. Total lesion area per cross-section was quantified (B) and lesion severity (C) was assessed, categorized as mild lesions (type I–III) and severe lesions (IV–V). Values represent mean ± SEM for ≥8 mice per group. ** p < 0.01 and *** p < 0.001 vs. chow.