Table 1.

Metabolic parameters.

	Chow	HFD	FFD
Body weight (g)	38.3 ± 1.5	52.3 ± 1.1 ***	48.7 ± 1.5 ***
Food intake (kCal/mouse/day)	13.5 ± 0.8	12.5 ± 0.6	14.9 ± 1.9
Liver weight (g)	1.8 ± 0.1	3.1 ± 0.2 ***	5.9 ± 0.4 *
Liver weight (% of body weight)	4.8 ± 0.2	3.5 ± 0.2 ***	7.1 ± 0.3 ***
Blood glucose (mM)	7.7 ± 0.4	7.7 ± 0.2	6.5 ± 0.3 **
Plasma insulin (ng/mL)	2.9 ± 0.6	14.7 ± 4.2 ***	3.9 ± 0.4
HOMA-IR	1.0 ± 0.2	4.9 ± 1.4 **	1.1 ± 0.1
Plasma cholesterol (mM)	8.0 ± 0.7	32.2 ± 3.7 ***	41.3 ± 4.7 ***
Plasma triglycerides (mM)	1.5 ± 0.3	6.5 ± 1.3 **	8.3 ± 1.2 ***
Plasma ALT (U/L)	53.3 ± 7.1	363.7 ± 64.8 **	348.6 ± 33.0 ***
Plasma AST (U/L)	88.2 ± 8.2	449.1 ± 69.1 ***	342.9 ± 58.4 ***
Plasma SAA (µg/mL)	39.6 ± 4.2	244.6 ± 54.6 ***	318.6 ± 73.3 ***
Plasma E-selectin (ng/mL)	61.3 ± 3.7	83.0 ± 10.1 *	83.7 ± 3.4 ***
Plasma MCP-1 (pg/mL)	33.2 ± 6.5	75.4 ± 11.2 **	70.7 ± 6.3 **

Ldlr−/−.Leiden mice were fed a healthy chow diet or fed a high-fat (HFD) diet containing lard fat or a fast food diet (FFD) containing milk fat for 28 weeks. Data represent mean ± SEM for n ≥ 8 mice/group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. chow. ALT: alanine aminotransferase, AST: aspartate aminotransferase, HOMA-IR: homeostasis model assessment of insulin resistance, MCP-1: monocyte chemoattractant protein-1, SAA: serum amyloid A.