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CDR1as/miR-7-5p Aggravates HPASMC Calcification via CNN3 and CAMK2D
(A) HPASMCs were incubated with CNN3- or CAMK2D-overexpressing plasmids with or without siCDR1as or miR-7-5p agomir, and calcium mineral deposits were assessed. (B) Transfection of siCDR1as or miR-7-5p agomir decreased the Runx2 level in Hyp HPASMCs, whereas the opposite phenomenon was observed after CNN3 or CAMK2D overexpression. Scale bars, 50 μm. All tests were performed at least three times.
