Figure 1.

Monitoring the real-time temperature of the tumor and body led to an effective application of magnetic hyperthermia. (a) Representative diagram of tumor and rectal temperatures after MNP injection (CS-MNP and 5FU-CS-MNP, 0.25 mg Fe per 100 mm³ tumor tissue and 0.22 to 0.55 mg 5FU per kg body weight) and exposure to an AMF (60 min at H = 15.4 kA/m, f = 410 kHz), (b) heat maps of the tumor surface temperatures as recorded with a thermographic camera, (c) mean CEM43T90, calculated for magnetic hyperthermia treatments and (d) representative µCT overlay images (bones: white, MNPs: red) taken at 24 h before the first (day −1) and second tumor therapy (day 6) and 24 h before the animal sacrifice (day 27) showing the clearance of MNPs over time. AMF: alternating magnetic field; MH: magnetic hyperthermia; µCT, micro computed tomography; MNP; magnetic nanoparticle; 5FU: 5-fluorouracil; CEM: cumulative equivalent minutes.