Figure 4.

Examples of Predicted Drug Combinations Supported by Independent Evidence

The candidate drug pairs (connected by red lines) that are identified based on NETPHIX modules and supported by the literature survey are shown.

(A–D) The panels are organized by different drug target pathways: (A) RTK inhibitors (inside blue boxes); (B) MEK/RAF inhibitors (turquoise boxes); (C) AKT/MDM2 inhibitors (magenta boxes); (D) HDAC inhibitors (orange boxes). The name of each drug is displayed next to its target protein, and their predicted combination partners are connected by red lines. Drugs with the same interaction partners are connected by brackets. The genes/nodes are color coded as follows: orange (DNA processing), magenta (PIK/AKT/mTOR pathway), turquoise (MAPK pathway), green (cell cycle), blue half-moons (Receptors Tyrosine Kinases), dark green (BRT is a non-receptor Tyrosine Kinase).