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. 2020 Oct 16;22:245. doi: 10.1186/s13075-020-02349-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Distribution of memory T helper (Th) cell subsets in paired blood and synovial fluid (SF) from patients with rheumatoid arthritis (RA). a Comparison of the proportions of total CD4⁺ lymphocytes, CD45RA^negCD4⁺ memory T cells and CXCR3⁺CD4⁺ T cells in blood and SF of patients with RA (n = 8). b OPLS-DA column loading plots showing the association of CD45RA^neg Th subset proportions (X-variables) to either SF or blood (Y-variables). c Comparison of the proportions of TPh, PD-1^highTFh, CXCR3⁺Th2, Th1, CXCR3⁺Th17, Th1Th17, PD-1⁺ TFh, Th17 and Th2 subsets of CD45RA^negCD4⁺ lymphocytes in blood and SF (gating strategy shown in Supplementary Figure 1). Horizontal bars indicate median. P value denotes the statistical significance of the difference between T cell proportions in blood and SF (Wilcoxon matched-pairs signed rank)