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. 2020 Oct 16;22:245. doi: 10.1186/s13075-020-02349-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) produce proinflammatory cytokines and chemokines when stimulated with T helper-associated cytokines. a The median fold change in IL-6, GM-CSF, CCL2, CXCL1, CXCL8, CCL11 and CXCL10 concentration in supernatants of stimulated as compared to unstimulated FLS. b IL-6 and GM-CSF levels and c CCL2, CXCL1, IL-8, CCL11 and CXCL10 levels in cell culture supernatant of RA (n = 7) FLS stimulated with IL-4, IL-13, IL-17A, IFNγ or TNF as measured by bead-based immunoassays and ELISA. Lines within boxes indicate the median. P value denotes the statistical significance of the difference between respective cytokine stimulus and media controls (Friedman test followed by Dunn’s multiple comparisons test)