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. 2020 Oct 16;19:370. doi: 10.1186/s12936-020-03445-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Proposed model for formation of parasitophorous duct plug. a Formation of tight junction (black rectangle) between merozoite apical and red blood cell (RBC) membranes. b Location of tight junction during entry of merozoite into RBC interior. c Parasitophorous duct plug formed from tight junction located at orifice of parasitophorous vacuole upon completion of merozoite ingress. d Disruption of parasitophorous duct plug by merozoite protease(s) to form opening on RBC surface for progeny merozoites release. M, merozoite; P, parasitophorous duct plug; PD, parasitophorous duct; PVM, parasitophorous vacuolar membrane; RBCM, red blood cell membrane