Fig. 4.

Concordance of the driver genetic alterations identified in primary tumors and matched relapses. Only genes altered in more than 10% of the study population and with a concordance of at least 60% between matched primary tumor and relapse were reported in the heatmap, with primary tumors on X-axis and matched recurrence samples on Y-axis. Darker blue color indicated a higher level of gene driver alteration concordance. The recurrent co-occurrence of copy number gains of CCND1, FGF19, and FGF3 genes was pin-pointed