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. 2020 Oct 2;11:581001. doi: 10.3389/fphar.2020.581001

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Copyright © 2020 Yang, Guo, Zhou, Gao, Wang, Wang and Niu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The carnosic acid potentiates meropenem inhibitory activity against E. coli. (A) Growth curves of E. coli ZC-YN3 cultured with different concentrations of carnosic acid; (B) Time-kill curves of E. coli ZC-YN3 with the indicated treatment. These values are the average of three independent experiments; (C) The microdilution checkerboard analysis showed the combined effects of carnosic acid and meropenem on E. coli ZC-YN3. The data are the results of four independent experiments.