TABLE 5.
Summary of AQP3 Antigen Recognitions at C Terminus and AA180-228 Expression Patterns in the Reported Carcinomas
| Normal Tissues | Dysplastic Tissues | Carcinomas | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. | Recognized Part of AQP3 | Antibody Host | Organ | Type | Expression Pattern | Expression Pattern | Type | Expression Pattern | References |
| 1 | C terminal | PR | Lung | BSE | MB | NP | SCC | 64% of cases showed loss of MB | Liu et al29 |
| 2 | C terminal | PR | Lung | BSE | MB | NP | BAC with invasive ADC | Invasive ADC showed loss of MB | Machida et al30 |
| 3 | C terminal | PR | Skin | Squamous epithelium | MB | NP | SCC | 100% of cases showed loss of MB | Voss et al18 |
| 4 | C terminal | PG | Urinary bladder | Urothelium | MB | NP | pT2 UC | 100% of cases showed loss of MB | Rubenwolf and colleagues31,32 |
| 5 | C terminal | PR | Urinary bladder | Urothelium | MB | NP | pT1 UC | 41% of cases showed loss of MB | Otto et al17 |
| 6 | C terminal | PR | Thyroid gland | C cells and follicular cells | Almost negative | NP | MTC | 90% of cases showed increased MB | Niu et al33 |
| 7 | C terminal | PG | Urinary bladder | Urothelium | MB | NP | pT2 UC | 67% of cases showed loss of MB | Rubenwolf et al34 |
| 8 | AA180-228 | PR | Oral cavity | Squamous epithelium | MB | Loss of MB | SCC | Generally the loss of MB | Matsuo and Kawano20 |
| 9 | C terminal | PR | Skin | Squamous epithelium | MB | NP | SCC | Generally the loss of MB | Seleit et al35 |
| 10 | C terminal | PR | Liver | Hepatocyte | Almost negative | NP | HCC | 93% of cases showed increased MB | Peng et al36 |
| 11 | C terminal | PR | Pancreas | Ductal cells | Almost negative | NP | PDA | Generally increased MB | Direito et al37 |
| 12 | C terminal | PR | Urinary bladder | Urothelium | NP | MB | pT2 UC | 100% of cases showed loss of MB | Breyer et al38 |
| 13 | C terminal | PR | Prostate gland | Glandular epithelial cells | MB | NP | High-risk PC | Generally the loss of MB | Brundl et al39 |
| 14 | C terminal | PR | Breast | Ductal cells | Almost negative | NP | TNBC | 61% of cases showed increased MB | Zhu et al40 |
| 15 | C terminal | PR | Oral cavity | Squamous epithelium | MB | Loss of MB | SCC | 84% of cases of the IF part showed loss of MB | This study |
| 16 | AA180-228 | PR | Oral cavity | Squamous epithelium | MB | Loss of MB | SCC | 92% of cases of the IF part showed loss of MB | This study |
AA indicates amino acid; ADC, pulmonary adenocarcinoma; AQP3, aquaporin 3; BAC, bronchioloalveolar carcinoma; BSE, bronchial surface epithelium; HCC, hepatocellular carcinoma; IF, invasive front; MB, membranous expression; MTC, medullary thyroid carcinoma; NP, not performed; PC, prostate adenocarcinoma; PDA, pancreatic ductal adenocarcinoma; PG, goat polyclonal; PR, rabbit polyclonal; pT1 UC, urothelial carcinoma invades connective tissue; pT2 UC, urothelial carcinoma invades muscle; SCC, squamous cell carcinoma; TNBC, triple-negative breast cancer.