Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 4;142(16):1562–1578. doi: 10.1161/CIRCULATIONAHA.119.044444

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — Gene expression changes in homozygous DNA methyltransferase(DNMT) 3A knockout engineered heart tissue(EHT).

Transcript abundance of (A) low-expression genes and (B) high-expression genes in DNMT3A^−/− EHTs. All values normalized to wild-type (dashed line); n=3 per group, **P<0.001, ***P<0.001. C, Pathway mapping of significantly differentially expressed genes in DNMT3A^−/− vs wild-type. Dotted line represents significance threshold of P<0.05. Red, cardiac-related; blue, signaling-related; yellow, metabolism-related pathways.