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. 2020 Sep 4;142(16):1562–1578. doi: 10.1161/CIRCULATIONAHA.119.044444

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© 2020 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Morphology of DNA methyltransferase(DNMT) 3A knockout engineered heart tissue(EHT).

Histological analysis of (A) wild-type and (B) DNMT3A^−/− EHTs. Left, Hematoxylin and eosin staining (H&E); scale bar, 50 µm. Middle, MLC2V staining; scale bar, 50 µm. Right, Lipid staining with Oil Red O; scale bar, 500 µm, red dots mark lipid accumulations. Transmission electron microscopy of wild-type (C) and knockout (D) EHTs showing intact sarcomeric structures but degenerated mitochondria in knockout EHT. Yellow arrowheads, sarcomeres; black arrowheads, mitochondria. Scale bar, 500 nm.