Table 1:
Characteristics of the BRCA carriers (Intervention+Control)
| Characteristics | Intervention group (n = 23) | Control group (n = 23) |
|---|---|---|
| Age (year), median (range) | 47.1 (35–71.3) | 47.3 (33.4–72.0) |
| Mutation | ||
| BRCA1 | 18 | 10 |
| 185delAG | 15 | 6 |
| 5382insC | 1 | 3 |
| c.3835delG | 1 | 0 |
| Tyr978X | 1 | 1 |
| BRCA2 | 5 | 13 |
| 6174delT | 4 | 13 |
| c.5549C>T;p.P1774L | 1 | 0 |
| Menopausal status | ||
| Postmenopausal | 18 | 19 |
| Premenopausal | 5 | 4 |
| Family historya, n | ||
| Any cancer cases | 23 | 23 |
| Breast cancer cases | 20 | 22 |
| Ovarian cancer cases | 13 | 11 |
| Pancreas cancer cases | 2 | 4 |
| BMI, median (range) | 24.46 (18.7–34.6) | 24.91 (18.9–35) |
| BSO | 17 | 18 |
| Smoking status, n | ||
| Never smoked | 20 | 21 |
| Current smoker | 1 | 1 |
| Past smoker | 2 | 1 |
| No. pregnancies, median (range) | 4 (1–9) | 3 (1–6) |
| No. children, median (range) | 3 (1–6) | 3 (1–5) |
| Physical activity (h/week), median (range) | 2 (0–5) | 2 (0–4) |
| Comorbidities, n | ||
| Hypothyroidism | 3 | 2 |
| Hypertension | 3 | 1 |
| Dyslipidemia | 9 | 4 |
| Ischemic heart disease | 1 | 0 |
| Asthma | 2 | 4 |
| COPD | 1 | 1 |
| Diabetes | 2 | 1 |
| Osteopenia/osteoporosis | 6 | 3 |
BMI, body mass index; BSO, bilateral salpingo-oophorectomy; COPD, chronic obstructive pulmonary disease.
aFirst- or second-degree relative.