Table 2.
The Association Between Orthostatic Blood Pressure Drop and Recovery With Changes in Cognitive Function After 1.5 y of Follow-up
| Unadjusted | Adjusteda | |||
|---|---|---|---|---|
| β (95% CI) | p | β (95% CI) | p | |
| Initial SBP drop | −0.3 (−5.4 to 4.9) | .922 | −0.5 (−6.2 to 5.3) | .872 |
| Initial DBP drop | 2.3 (−2.8 to 7.4) | .376 | 1.9 (−3.4 to 7.2) | .474 |
| 1-min SBP recovery | 4.7 (−0.3 to 6.8) | .067 | 5.6 (0.4 to 10.8) | .035 |
| 1-min DBP recovery | 5.6 (0.5 to 10.6) | .033 | 7.6 (2.3 to 13.0) | .006 |
| 5-min SBP recovery | 6.3 (1.3 to 7.7) | .015 | 6.6 (1.3 to 11.9) | .015 |
| 5-min DBP recovery | 4.1 (−2.0 to 10.2) | .183 | 4.4 (−2.0 to 10.8) | .176 |
Notes: ADAS-cog = Alzheimer’s disease Assessment Scale—cognitive subscale; CI = confidence interval; BP = blood pressure; DBP = diastolic blood pressure; SBP = systolic blood pressure. Results from regression analyses of BP response and change in ADAS-cog. For the initial drop, groups with a smaller or larger drop were compared (median split). For recovery, impaired recovery (<100% of sitting BP) was compared with unimpaired recovery (≥100% of sitting BP).
aThe adjusted model is corrected for intervention group, age, and sex.