Table 4.
Characteristic | Overall oral cancers (n = 161)*, † | Oral cancers <12 mo after leukoplakia diagnosis (n = 73)* | Oral cancers ≥12 mo after leukoplakia diagnosis (n = 88)* |
---|---|---|---|
Sensitivity, % | 59.6 | 65.8 | 54.5 |
Specificity, % | 62.1 | 62.9 | 62.6 |
PPV, % | 5.1 | 2.5 | 2.5 |
NPV, % | 97.8 | 99.2 | 98.7 |
cNPV (=1-NPV), % | 2.2 | 0.8 | 1.3 |
Versus oral cancer incidence as the gold-standard. Biopsy within +/- 30 days of leukoplakia diagnosis. Analyses were conducted in the entire leukoplakia cohort (n = 4886). cNPV = complement of the negative predictive value; NPV = negative predictive value; PPV = positive predictive value.
Of 161 oral cancers, 96 preceding leukoplakias were biopsied and 65 preceding leukoplakias were not biopsied. See Supplementary Figure 1 (available online) for additional details.