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. 2020 Jul 18;41(10):1353–1362. doi: 10.1093/carcin/bgaa077

Figure 2.

Figure 2.

Proportions of the mSNPs predicted to be pathogenic by FATHMM. There is a positive linear association between the number of counts and the proportion of mutations predicted to be pathogenic in first nine categories (small open circles) (Pearson r = 0.96, n = 8, P = 0.00004). Categories with 10–50 counts (small filled circles) or more (a large filled circle) show no association between the number of counts and the proportion of pathogenic mutations (Pearson r = −0.06, n = 39, P = 0.72). Increasing variance after nine COSMIC counts is likely due to small sample sizes in those groups (see Figure 1).