Table 3.
Frequent mutational SNPs reported in the Catalog of published GWASs as cancer risk associated
| rs ID | COSMIC ID | position | Ref | Alt | Gene | SNP | Count | MAF | GWAS cancer type | PubMed ID | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs10934853 | 87135561 | 3:128319530 | C | A | EEFSEC | intronic | 24 | 0.43 | Prostate cancer | 19767754 | 3.1E-10 | 1.12 |
| rs10936599 | 89751629 | 3:169774313 | C | T | MYNN | syn | 12 | 0.22 | Colorectal cancer | 20972440 | 3E-8 | 1.04 |
| rs1801516 | 88127386 | 11:108304735 | G | A | ATM | nonsyn | 15 | 0.09 | Melanoma | 21983787 | 3.3E-09 | 1.19 |
| rs2274223 | 94964513 | 10:94306584 | A | G | PLCE1 | nonsyn | 26 | 0.31 | Esophageal cancer | 21642993 | 4E-20 | 1.35; 1.34 |
| rs2292884 | 88401131 | 2:237534583 | A | G | MLPH | nonsyn | 72 | 0.35 | Prostate cancer | 21743057 | 4E-8 | 1.14 |
| rs3765524 | 94964492 | 10:94298541 | C | T | PLCE1 | nonsyn | 24 | 0.32 | Esophageal and gastric cancer | 20729852 | 2E-9 | 1.35 |
| rs3781264 | 94964531 | 10:94310618 | A | G | PLCE1 | intronic | 18 | 0.25 | Esophageal and gastric cancer | 20729852 | 4E-9 | 1.36 |
| rs5768709 | 103312035 | 22:48533757 | A | G | FAM19A5 | intronic | 15 | 0.35 | Pancreatic cancer | 22158540 | 1E-10 | 1.25 |
| rs6983267 | 151207513 | 8:127401060 | G | T | CASC8; CCAT2 | intronic; non-coding | 16 | 0.37 | Colorectal and prostate cancer | 28960316; 26034056 | 2E-21; 3E-27 | 1.18; 1.25 |
| rs8034191 | 106432881 | 15:78513681 | T | C | HYKK | intronic | 16 | 0.26 | Lung cancer | 19654303 | 3E-26 | 1.29 |
| rs8100241 | 99852108 | 19:17282085 | G | A | ANKLE1; USHBP1 | nonsyn; intronic | 11 | 0.46 | Breast cancer | 22976474 | 4E-8 | 1.14 |
| rs9364554 | 86706928 | 6:160412632 | C | T | SLC22A3 | intronic | 10 | 0.21 | Prostate cancer | 26034056 | 6E-12 | 1.14 |