Figure 1.
Apigenin treatment relieved frailty and improved muscle function in aged mice. (A) Mean frailty index (FI) scores were evaluated in young mice and (B) in old mice treated either with apigenin (AP) at dose of 25 mg·kg−1·day−1 (Old + AP25, low dose), 50 mg·kg−1·day−1 (Old + AP50, middle dose), or 100 mg·kg−1·day−1 (Old + AP100, high dose), or without treatment as Old control mice. The muscle function was detected by (C) grip strength and (D) running distance. Data are presented as the mean ± SD (n = 8–10). †p < .05, versus 16 months (in the Old group); *p < .05, versus the Old group (25 months).