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HER4-biased cell-based reporter activity in top combinatorial library hits.
| Clone name | EC50 (nM) | Ratio | Positions | |
|---|---|---|---|---|
| HER2/HER4 Luc | HER2/HER3 Luc | |||
| NRG1 | 0.3 | 0.4 | 1 | Wild type |
| H2T | 0.5 | 0.7 | 2 | H2T |
| 2G2 | 0.4 | 4.0 | 11 | H2E, K24E, P29H |
| 1D2/1C11/1H8 | 0.3 | 5.6 | 17 | H2E, K24G |
| 1F7 | 0.4 | 15.7 | 36 | H2E, K24G, P29H |
Luc luciferase.
