TABLE 3.

Univariate Adjusted Cox Regression Models of Time to Relapse From Validation Phase for Each Measured miRNA

All patients						Patients after total resection
Factor	HR	1/HR	95% Cl range		P value	Factor	HR	1/HR	95% Cl range		P value
miR-146a-5p based model
Age at diagnosis	0.99	1.01	0.97	1.01	.436	Age at diagnosis	1.01	0.99	0.98	1.04	.709
Sex: male	1.68	0.59	0.84	3.37	.142	Sex: male	1.15	0.87	0.47	2.82	.759
WHO grade	1.63	0.61	1.07	2.50	.024	WHO grade	1.86	0.54	1.06	3.24	.029
Nonconvex. location	0.63	1.60	0.33	1.18	.148	Nonconvex. location	0.54	1.85	0.23	1.25	.150
Partial resection	3.16	0.32	1.67	6.00	4.24E-04	–	–	–	–	–	–
miR-146a-5p	1.34	0.74	1.10	1.63	.003	miR-146a-5p	1.37	0.73	1.07	1.76	.014
miR-15a-5p based model
Age at diagnosis	0.99	1.01	0.97	1.01	.254	Age at diagnosis	0.99	1.01	0.97	1.02	.656
Sex: male	2.77	0.36	1.45	5.27	.002	Sex: male	1.69	0.59	0.72	3.95	.228
WHO grade	1.37	0.73	0.91	2.08	.132	WHO grade	1.85	0.54	1.07	3.18	.027
Nonconvex. location	0.69	1.46	0.37	1.28	.236	Nonconvex. location	0.65	1.55	0.28	1.50	.310
Partial resection	3.67	0.27	1.92	7.02	8.52E-05	–	–	–	–	–	–
miR-15a-5p	0.94	1.06	0.84	1.05	.283	miR-15a-5p	0.96	1.04	0.82	1.11	.573
miR-331-3p based model
Age at diagnosis	1.00	1.00	0.97	1.02	.827	Age at diagnosis	1.01	0.99	0.98	1.04	.443
Sex: male	1.43	0.70	0.67	3.03	.354	Sex: male	1.12	0.89	0.44	2.87	.811
WHO grade	1.33	0.75	0.86	2.05	.200	WHO grade	1.53	0.65	0.86	2.73	.146
Nonconvex. location	0.58	1.72	0.31	1.10	.095	Nonconvex. location	0.46	2.17	0.19	1.11	.085
Partial resection	3.87	0.26	2.03	7.38	4.11E-05	–	–	–	–	–	–
miR-331-3p	1.45	0.69	1.17	1.79	.001	miR-331-3p	1.43	0.70	1.10	1.87	.007

Significant factors are marked in bold.